It is often assumed that the connection between
lower-limb arthritis and excess body weight is merely due to the increased load
these susceptible joints have to support, usually over many years, but it has been
discovered that damage to the joint surface is due to a metabolic effect,
caused by the release of the cytokines from adipose tissue. A direct
inflammatory action in the process may lead to arthritis. According to a study
when the relative risk of radiographic osteoarthritis of the knee was checked for
various weight groups, age, physical activity level, and uric acid level, It
was discovered that women in the heaviest quintile for weight had more than
double the risk of osteoarthritis in the knee, whereas men had 1.5 times the
risk.
A study conducted at St Thomas Hospital discovered
that obese people developed arthritis not only in knee but in the hands as
well. People developed arthritis in their carpometacarpal joints, not to forget
that these are not the weight bearing joints.
This implies a metabolic cause and suggests the
scope for prevention of osteoarthritis by weight loss.
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